Akira
Akira was a young boy who developed transcendent psionic, nearly god- like abilities when serving as a test subject for secret government ESP experiments in the 1980s. He subsequently lost control of this power and annihilated Tokyo in 1988. After the cataclysmic event, Akira's dead body was recovered and subjected to every test known to modern science, which proved unable to solve the mystery.
Shotaro Kaneda
Kaneda is a carefree gang-leader who boasts a custom-modified motorcycle. He and Tetsuo have been best friends since early childhood. He is brash and not above teasing Tetsuo despite feeling affection for him as a younger brother. Upon rescuing Kei, Kaneda becomes involved in the activities of her group of anti-government guerillas in hopes of locating Tetsuo.
Tetsuo Shima
Tetsuo is shown as a black sheep in the gang he and Kaneda are part of, and quietly suffers from a deeply rooted inferiority complex. He admires his friend yet at the same time strongly resents his own reliance upon him. After his psychokinetic abilities manifest, Tetsuo quickly becomes Kaneda's nemesis; he desires Kaneda's motorcycle (a symbol of status and power), and seeks to prove himself supremely powerful, without need of protection.
Kei
A young female revolutionary whom Kaneda meets and becomes enamoured with on his quest to find Tetsuo. She is a member of an anti-government faction that Ryu and Nezu are also involved in. Although she does not possess preternatural abilities, Kei is employed by the espers as a type of medium on several occasions.